• Berberine CM
1 1

Wholesome Root Nutraceuticals

Berberine CM

Berberine CM

$54.60 USD
$54.60 USD
Sale Sold out
Shipping calculated at checkout.

≈ $1.82 per serving · 30 servings (3 capsules each)
  • All supplement sales are final. Damaged or incorrect orders made right.
  • Secure checkout — encrypted payment.
  • Ships in 1–2 business days · Sold by Hudson Valley Integrative Health.

Berberine with alpha-lipoic acid — for everyday antioxidant support and healthy gut balance.

At a glance

  • Clinician-chosen
  • Gluten-free
  • Corn-free
  • Yeast-free
  • No artificial colors or flavors
  • Balanced gut bacteria
  • Steady blood sugar*
  • Healthy cholesterol*
  • Antioxidant support

*Supports healthy levels already within the normal range.

  • Third-party tested
  • cGMP-compliant facility
  • Certificate of Analysis on request
  • Clean by design

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

View full details

Full transparency · No proprietary blends

What’s inside — and why.

Ingredients · 2

  • Actives

Berberine

1 g · as Berberine HCl

Structure / Function

A natural compound from plants like goldenseal and barberry. It does two things. It helps keep blood sugar and cholesterol steady when they are already in a normal range. And it helps keep the bacteria in your gut in a healthy mix.

Berberine does two separate jobs. First, it flips on your cells' built-in energy switch, which scientists call AMPKYour cells' built-in energy switch: flip it on and cells burn sugar and fat for fuel instead of storing them.. That switch tells your cells to pull sugar and fat out of your blood and burn them for fuel instead of storing them. That is what keeps blood sugar and cholesterol steady in a normal range. Second, and separately, berberine works right on the bacteria in your gut, your microbiomeThe community of trillions of bacteria in your gut that help with digestion and immune balance., nudging the mix toward a healthier balance.

Evidence · 3 studies
  • Found that berberine can shift the mix of bacteria in your gut toward a healthier balance. Zhang et al. · PLoS One · 2012PubMed →
  • In a study in people, berberine helped keep fasting blood sugar steady in a normal range. Yin et al. · Metabolism · 2008PubMed →
  • Showed how berberine prompts the liver to take up more cholesterol. It uses a different route than statin drugs. Kong et al. · Nature Medicine · 2004PubMed →

Alpha Lipoic Acid

200 mg · an antioxidant your body also makes on its own

Structure / Function

It protects your cells from everyday wear (the damage from free radicals) and helps them turn food into energy. It also helps recharge other antioxidants, like vitamins C and E.

First, what is an antioxidantA protector molecule. It steps in and defuses the unstable particles that would otherwise wear your cells down.? Just by living, plus stress and pollution, your body makes unstable bits called free radicalsUnstable particles your body makes just from normal living (plus stress and pollution) that slowly damage cells over time, a bit like rust on metal.. They slowly wear your cells down, a bit like rust on metal. An antioxidant steps in and defuses them. ALA is an unusual one. It dissolves in both water and fat, so it reaches parts of a cell most antioxidants cannot. And once it is spent, it re-charges your other antioxidants, like vitamins C and E, so they can keep working.

Evidence · 3 studies
  • Explained how ALA defuses cell-damaging free radicalsUnstable particles your body makes just from normal living (plus stress and pollution) that slowly damage cells over time, a bit like rust on metal.. It also re-charges other antioxidants, like vitamins C and E. Shay et al. · Biochim Biophys Acta · 2009PubMed →
  • The classic paper showing ALA works in both the watery and the fatty parts of a cell. Packer et al. · Free Radic Biol Med · 1995PubMed →
  • In a trial with a dummy-pill group, ALA helped the body move sugar out of the blood. The sugar goes into cells, where the body burns it for energy. Jacob et al. · Free Radic Biol Med · 1999PubMed →

These summaries describe each ingredient's role in normal physiology — they are not a claim to diagnose, treat, cure, or prevent any disease.

Where the science points

Berberine CM — influence by impact

Influence by impact

  • Gut40%
  • Infection20%
  • Hormones20%
  • Environmental20%

Across the R.E.S.E.T. 10, Berberine CM's strongest evidence is helping rebalance the gut microbiome, with everyday toxic-element defense and support for normal insulin use close behind.

InfectionNutrition Gut EnvironmentalMedicationLifestyleMind & MoodGenetics HormonesSubstance

Hover a label to see what each one means.

Top focus

  • Gut microbiome balance
  • Toxic-element defense
  • Insulin balance

Across the R.E.S.E.T. 10, Berberine CM's strongest evidence is helping rebalance the gut microbiome, with everyday toxic-element defense and support for normal insulin use close behind.

See all 10 categories
  • Gut 4/5
  • Infection 2/5
  • Hormones 2/5
  • Environmental 2/5
  • Substance 0/5
  • Nutrition 0/5
  • Mind & Mood 0/5
  • Medication 0/5
  • Lifestyle 0/5
  • Genetics 0/5
Studies behind these scores
  1. Zhang et al. · PLoS One · 2012PubMed →
  2. Nazari & Ghaheri · Clin Ther · 2024PubMed →
  3. Vafaee et al. · Naunyn-Schmiedeberg's Arch Pharmacol · 2025PubMed →

Scores show each ingredient's share of evidence-graded support for normal body function. They are not a measure of diagnosing, treating, curing, or preventing any disease.

Dr. Somer DelSignore, DNP, PNP-BC, MAPS

Your guide

Chosen by a clinician — not an algorithm.

Every Wholesome Root Nutraceuticals formula is selected by Dr. Somer DelSignore, DNP, PNP-BC, MAPS .You're not buying off a shelf. You're following a guide who has been where you are.

Meet your guide

DNP · Pediatric Nurse Practitioner · MAPS Fellow

How do I take Berberine CM?

The right amount is different for each person. Your practitioner will set the dose and the schedule that suits you. Take it exactly as they direct, with a meal.

My child can't swallow capsules — can I open it?

Yes. You can open the capsule and stir the contents into a little food or juice. For children, use Berberine CM only with guidance from your healthcare practitioner.

Should I start at the full amount?

Usually not. With berberine it is common to start low and build up slowly. The pace is different for each person, so follow what your practitioner directs as they see how your body responds.

When's the best time to take it?

With a meal. Taking it alongside food is gentler on the stomach.

Can I take it with my other supplements or medication?

Berberine is often paired with a daily probiotic. It can also interact with some medicines. Check with your practitioner before combining it with anything. We are glad to help you start that conversation.

What if it doesn't agree with me?

Everyone's different, and some people do best at a lower amount. If it doesn't sit well, ease back or pause, and talk to your guide about the right amount for you.

You're not alone

Still not sure? You don't have to choose alone.

Tell us where you're starting from, and we'll walk you to the right first step — no pressure, no guesswork.

Talk to your guideStart here