• BioBust
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Hudson Valley Integrative Health

BioBust

BioBust

$39.10 USD
$39.10 USD
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≈ $0.65 per serving · 60 servings (1 soft gel capsule each)
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BioBust — a fermented-soy nattokinase enzyme that supports healthy, comfortable circulation and normal blood flow.

At a glance

  • Fermented-soy enzyme
  • From traditional natto
  • Contains soy
  • Soft gel · 1 per serving
  • 60 per bottle
  • Supports healthy, comfortable blood flow
  • Helps keep hands and feet warm if you tend to run cold
  • Supports your body's own antioxidant defenses

*Supports normal, healthy function. It is not a treatment for any health condition.

  • Third-party tested
  • cGMP-compliant facility
  • Certificate of Analysis on request
  • Clean by design

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Full transparency · No proprietary blends

What’s inside — and why.

Ingredients · 1

  • Actives

Nattokinase

100 mg

Structure / Function

Nattokinase is an enzyme. An enzyme is a tiny worker your body uses to get jobs done. This one comes from nattoA traditional food made by fermenting soybeans; it's where nattokinase comes from., a traditional fermented-soy food eaten for a long time. It supports healthy, comfortable blood flow — the easy warmth you feel in your hands and feet when you tend to run cold.

It works with your body's normal circulation. In a small study of healthy men, a single dose helped their skin warm back up faster after a cold dip. That points to comfortable, healthy blood flow near the surface of the skin. It also supports your body's own antioxidantA protector molecule — it steps in and defuses the unstable particles that would otherwise wear your cells down. defenses, which help keep your everyday balance steady.

Evidence · 3 studies
  • A small study looked at healthy men. One dose helped their skin warm back up faster after a cold dip. That is a sign of healthy, comfortable blood flow. Nara N, Hamaoka T. Heliyon, 2023 (PMID 37483751) — double-blind, placebo-controlled crossover in 9 healthy men.PubMed →
  • That same warmth-and-comfort effect may matter most for people who tend to run cold, like keeping hands and feet from getting too chilled. Nara N, Hamaoka T. Heliyon, 2023 (PMID 37483751) — authors note it may be more meaningful for those with a cold-sensitive constitution.PubMed →
  • Lab work shows nattokinase supports the body's own antioxidant defenses. Those defenses help your body stay in a steady, healthy balance. Li YL, Lee IT. J Dent Sci, 2026 (PMID 41585176) — nattokinase supports the body's Nrf2 antioxidant-response pathway in human cells.PubMed →

These summaries describe each ingredient's role in normal physiology — they are not a claim to diagnose, treat, cure, or prevent any disease.

Where the science points

BioBust — influence by impact

Influence by impact

  • Lifestyle60%
  • Environmental40%

BioBust is a fermented-soy enzyme. It supports healthy, comfortable blood flow. Early lab work also points to support for your body's own antioxidant defenses.

InfectionNutritionGut EnvironmentalMedication LifestyleMind & MoodGeneticsHormonesSubstance

Hover a label to see what each one means.

Top focus

  • Comfortable, healthy circulation
  • Support for antioxidant defenses

BioBust is a fermented-soy enzyme. It supports healthy, comfortable blood flow. Early lab work also points to support for your body's own antioxidant defenses.

See all 10 categories
  • Lifestyle 3/5
  • Environmental 2/5
  • Substance 0/5
  • Nutrition 0/5
  • Mind & Mood 0/5
  • Medication 0/5
  • Infection 0/5
  • Hormones 0/5
  • Gut 0/5
  • Genetics 0/5
Studies behind these scores
  1. Nara N, Hamaoka T. Heliyon, 2023 (PMID 37483751) — double-blind, placebo-controlled crossover in 9 healthy men.PubMed →
  2. Li YL, Lee IT. J Dent Sci, 2026 (PMID 41585176) — nattokinase supports the body's Nrf2 antioxidant-response pathway in human cells.PubMed →

Scores show each ingredient's share of evidence-graded support for normal body function. They are not a measure of diagnosing, treating, curing, or preventing any disease.

Dr. Somer DelSignore, DNP, PNP-BC, MAPS

Your guide

Chosen by a clinician — not an algorithm.

Every Wholesome Root Nutraceuticals formula is selected by Dr. Somer DelSignore, DNP, PNP-BC, MAPS .You're not buying off a shelf. You're following a guide who has been where you are.

Meet your guide

DNP · Pediatric Nurse Practitioner · MAPS Fellow

What is BioBust?
It's a fermented-soy enzyme called nattokinase. It comes from natto, a traditional food made by fermenting soybeans. BioBust supports healthy, comfortable blood flow and your body's normal antioxidant balance.
What does it actually do?
It supports healthy circulation — the easy, comfortable warmth you feel when blood flows well. In a small study of healthy men, a single dose helped their skin warm back up faster after a cold dip.
I always have cold hands and feet. Could this help?
It supports comfortable, healthy blood flow, and the study authors noted the effect may matter most for people who tend to run cold. It's about supporting normal warmth, not fixing a health problem. If cold hands and feet really bother you, talk with your practitioner.
What's the antioxidant part about?
Your body makes its own defenses that keep your everyday balance steady. Lab work shows nattokinase supports those defenses. We keep this simple: it supports the normal balance your body already works to hold.
Does this contain soy?
Yes. Nattokinase comes from natto, which is made from fermented soybeans. So BioBust contains soy. If you're allergic to soy, or you're not sure, please check with your practitioner before you take it.
How much should I take, and is it right for me?
Everyone is different, so the right amount and the right fit are personal. Your practitioner knows your full picture and can guide you. Please check with them before you start.
Can I take this with my other medicines or supplements?
That's a question for your practitioner. They can look at everything you take and let you know what's best for you. Always run it by them first.

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