• Hist Assist
1 1

Hudson Valley Integrative Health

Hist Assist

Hist Assist

$50.90 USD
$50.90 USD
Sale Sold out
Shipping calculated at checkout.

≈ $0.84 per serving · 60 servings (2 capsules each)
  • All supplement sales are final. Damaged or incorrect orders made right.
  • Secure checkout — encrypted payment.
  • Ships in 1–2 business days · Sold by Hudson Valley Integrative Health.

Histamine and mast-cell balance — quercetin and stinging nettle for a calm, steady histamine response, plus vitamin C for everyday immune resilience.

At a glance

  • Histamine & mast-cell balance
  • Seasonal immune support
  • Antioxidant support
  • Practitioner-selected formula
  • Supports a calm, steady histamine and mast-cell response, day in and day out
  • Helps your body hold steady when pollen is high and the seasons feel tough
  • Adds vitamin C for everyday immune and antioxidant support

*Supports normal, healthy function. It is not a treatment for any health condition.

  • Third-party tested
  • cGMP-compliant facility
  • Certificate of Analysis on request
  • Clean by design

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

View full details

Full transparency · No proprietary blends

What’s inside — and why.

Ingredients · 4

  • Actives

Quercetin Dihydrate

400 mg

Structure / Function

Quercetin is a plant flavonoidA natural color compound found in plants and many everyday foods, like onions, apples, and tea. — the natural color found in foods like onions and apples. It's the star of this formula. It helps your body keep a calm, steady histamineA natural messenger your body makes; it's part of how your body responds day to day, and your body keeps its own steady balance of it. response.

Quercetin works with your mast cellsImmune cells in your body that store histamine and release it as part of your normal response to things like pollen. — the immune cells that store and release histamine. It helps them stay calm and steady, so your body can hold a balanced histamine response. Quercetin is also a well-studied antioxidantA protector molecule. It steps in and defuses the unstable particles that would otherwise wear your cells down.. That means it helps neutralize the everyday free radicalsUnstable particles your body makes just from normal living (plus stress and pollution) that slowly damage cells over time, a bit like rust on metal. that form from normal living.

Evidence · 3 studies
  • In lab studies on human mast cellsImmune cells in your body that store histamine and release it as part of your normal response to things like pollen., quercetin helped calm the histamine those cells let out. That's a big part of a balanced response. Weng Z, Theoharides TC, et al. PLoS One, 2012 (PMID 22470478)PubMed →
  • A 2023 research review looked at food-based compounds. It listed quercetin among the top helpers for keeping mast cellsImmune cells in your body that store histamine and release it as part of your normal response to things like pollen. calm and balanced. Kaag S, Lorentz A. Cells, 2023 (PMID 37998337)PubMed →
  • Vitamin C supports the everyday work of your immune systemYour body's built-in defense team that helps keep you well day to day.. It also lends antioxidantA protector molecule. It steps in and defuses the unstable particles that would otherwise wear your cells down. support. Carr AC, Maggini S. Nutrients, 2017 (PMID 29099763)PubMed →

Stinging Nettle

400 mg

Structure / Function

People have reached for stinging nettle leaf for seasonal support for a very long time. Here it's quercetin's partner, and the two work as a team.

Nettle works with the same mast cellsImmune cells in your body that store histamine and release it as part of your normal response to things like pollen. as quercetin. Together they make a classic, well-studied pair. Side by side, they support a calm, balanced histamine response when the seasons get tough.

Vitamin C

300 mg

Structure / Function

Your body needs vitamin C every day, but it can't make its own. This daily dose helps your immune systemYour body's built-in defense team that helps keep you well day to day. do what it naturally does.

At 300 mg (333% of the Daily Value), vitamin C supports the normal, everyday work of your immune cells. It's also a strong antioxidantA protector molecule. It steps in and defuses the unstable particles that would otherwise wear your cells down.. So it helps protect your cells from the everyday free radicalsUnstable particles your body makes just from normal living (plus stress and pollution) that slowly damage cells over time, a bit like rust on metal. that form from normal living.

N-Acetyl-L-Cysteine USP

50 mg

Structure / Function

This is a small amount of cysteineOne of the amino-acid building blocks your body uses, and the key piece it needs to make its own master antioxidant, glutathione., an amino acidOne of the small building blocks your body strings together to make proteins and other things it needs every day. building block your body uses every day. Here it plays a quiet supporting role that rounds out the formula.

At 50 mg, this is a small companion ingredient that rounds out the formula. Your body uses cysteine as one of its everyday building blocks.

These summaries describe each ingredient's role in normal physiology — they are not a claim to diagnose, treat, cure, or prevent any disease.

Where the science points

Hist Assist — influence by impact

Influence by impact

  • Nutrition37%
  • Infection37%
  • Environmental25%

This blend leans on quercetin and stinging nettle to support a calm, steady histamine response. Vitamin C adds everyday immune and antioxidant support.

Infection NutritionGut EnvironmentalMedicationLifestyleMind & MoodGeneticsHormonesSubstance

Hover a label to see what each one means.

Top focus

  • Calm, steady histamine and mast-cell balance
  • Vitamin C for daily nutrient support
  • Everyday antioxidant support

This blend leans on quercetin and stinging nettle to support a calm, steady histamine response. Vitamin C adds everyday immune and antioxidant support.

See all 10 categories
  • Nutrition 3/5
  • Infection 3/5
  • Environmental 2/5
  • Substance 0/5
  • Mind & Mood 0/5
  • Medication 0/5
  • Lifestyle 0/5
  • Hormones 0/5
  • Gut 0/5
  • Genetics 0/5
Studies behind these scores
  1. Weng Z, Theoharides TC, et al. PLoS One, 2012 (PMID 22470478)PubMed →
  2. Kaag S, Lorentz A. Cells, 2023 (PMID 37998337)PubMed →
  3. Carr AC, Maggini S. Nutrients, 2017 (PMID 29099763)PubMed →

Scores show each ingredient's share of evidence-graded support for normal body function. They are not a measure of diagnosing, treating, curing, or preventing any disease.

Dr. Somer DelSignore, DNP, PNP-BC, MAPS

Your guide

Chosen by a clinician — not an algorithm.

Every Wholesome Root Nutraceuticals formula is selected by Dr. Somer DelSignore, DNP, PNP-BC, MAPS .You're not buying off a shelf. You're following a guide who has been where you are.

Meet your guide

DNP · Pediatric Nurse Practitioner · MAPS Fellow

What is Hist Assist for?
It's a daily formula for histamine balance. Quercetin and stinging nettle help your body hold a calm, steady [[histamine]] response. Vitamin C adds everyday immune and [[antioxidant]] support for the seasons when your body is most challenged.
How does it work?
Quercetin and nettle work with your [[mast cells]] — the immune cells that store [[histamine]]. They help those cells stay calm and balanced. Vitamin C supports the normal, everyday work of your [[immune system]].
Is this an allergy medicine or an antihistamine?
No. Hist Assist is a supplement, not a medicine. It's made to support your body's own calm, balanced histamine response. It is not made to act on any health condition. If you have a health concern, talk with your practitioner.
How much should I take, and is it right for me?
The label lists a serving of 2 capsules. For what's right for you — your dose, your timing, and whether this fits your situation — check with your practitioner. They know your full picture.
Can my kids take it, or can I take it with my other medicines?
Please ask your practitioner first. They can tell you if it fits your child. They can also check it against your other medicines. We don't give that advice here. That call belongs to you and your practitioner.
What's the stinging nettle and the NAC doing in here?
Stinging nettle is quercetin's traditional partner. Together they make a classic pair for histamine balance. The NAC is a small amount of [[cysteine]], an [[amino acid]] your body uses. Here it's a quiet helper that rounds out the formula.

You're not alone

Still not sure? You don't have to choose alone.

Tell us where you're starting from, and we'll walk you to the right first step — no pressure, no guesswork.

Talk to your guideStart here