• Hist Assist JR
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Hudson Valley Integrative Health

Hist Assist JR

Hist Assist JR

$23.10 USD
$23.10 USD
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≈ $0.38 per serving · 60 servings (1 chewable tablet each)
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Everyday histamine balance support for kids. A chewable quercetin, nettle, and bromelain blend that supports your child's own normal histamine balance.

At a glance

  • Great-tasting chewable
  • For kids during seasonal changes
  • Quercetin + nettle + bromelain blend
  • 83% DV Vitamin C
  • Practitioner-selected formula
  • Quercetin supports mast cells in maintaining their normal function. That is part of how your child's body keeps its own everyday histamine balance.
  • A plant blend that supports a healthy, normal immune response year-round.
  • Vitamin C helps your kid keep a healthy immune system. It adds everyday antioxidant support. Each chewable has 83% of the Daily Value.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

  • Third-party tested
  • cGMP-compliant facility
  • Certificate of Analysis on request
  • Clean by design

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Full transparency · No proprietary blends

What’s inside — and why.

Ingredients · 5

  • Actives

Quercetin Dihydrate

100 mg

Structure / Function

Quercetin is a plant flavonoidA natural color compound found in plants and many everyday foods, like onions, apples, and tea.. That's a natural color compound in foods like onions and apples. It's the heart of this blend. Your child's body makes histamineA natural messenger your body makes; it's part of how your body responds day to day, and your body keeps its own steady balance of it. as part of its normal, everyday immune balance. Quercetin helps steady the mast cellsImmune cells in your body that store histamine and release it as part of your normal response to things like pollen. that hold it. That way your kid's body can stay calm.

Quercetin works on the mast cellsImmune cells in your body that store histamine and release it as part of your normal response to things like pollen.. Those are the cells that hold and release histamineA natural messenger your body makes; it's part of how your body responds day to day, and your body keeps its own steady balance of it.. It helps keep them steady. That way your child's body can maintain its own normal histamine balance. Quercetin is also an antioxidantA protector molecule. It steps in and defuses the unstable particles that would otherwise wear your cells down.. It helps protect cells from everyday free radicalsUnstable particles your body makes just from normal living (plus stress and pollution) that slowly damage cells over time, a bit like rust on metal..

Evidence · 3 studies
  • Quercetin helps steady the mast cellsImmune cells in your body that store histamine and release it as part of your normal response to things like pollen. that release histamineA natural messenger your body makes; it's part of how your body responds day to day, and your body keeps its own steady balance of it.. This supports your child's normal, everyday histamine balance. Kaag & Lorentz, Cells 2023 (PMID 37998337); Naso, Trincianti, Tosca & Ciprandi, Nutrients 2025 (PMID 40362785)PubMed →
  • A plant blend of quercetin, stinging nettle, and bromelainAn enzyme from pineapple; here it helps the body take in the quercetin in the blend. supports a healthy immune response. It supports normal immune function. Devkota & Hansbro, Molecules 2022 (PMID 36014458); Naso et al., Nutrients 2025 (PMID 40362785)PubMed →
  • Vitamin C helps keep your kid's immune system in good shape. It also gives them a bit of everyday antioxidantA protector molecule. It steps in and defuses the unstable particles that would otherwise wear your cells down. support. Lykkesfeldt & Carr, Adv Nutr 2023 (PMID 37992968)PubMed →

Stinging Nettle Leaf

100 mg

Structure / Function

Stinging nettle is a leafy plant. People have used it in food and tea for a long time. It brings plant compounds called flavonoidsA family of natural plant compounds, found in many fruits and vegetables, that act as antioxidants.. These give everyday antioxidantA protector molecule. It steps in and defuses the unstable particles that would otherwise wear your cells down. support. It works with the other ingredients to support normal immune function.

Nettle leaf carries natural plant compounds called flavonoidsA family of natural plant compounds, found in many fruits and vegetables, that act as antioxidants.. These act as antioxidantsSubstances that help protect your cells from everyday damage by free radicals.. Paired with quercetin, it helps support your kid's immune system as the seasons change.

Bromelain

25 mg

Structure / Function

Bromelain is an enzymeA natural protein that helps a specific job get done in the body, like breaking down or taking in other substances. from pineapple. It's not the star here. It's the helper. It's in the blend to help your kid's body take in the quercetin.

Bromelain is here as a helper. Its job is to help the body take in the quercetin. That way the main flavonoidA natural color compound found in plants and many everyday foods, like onions, apples, and tea. can do its work. Think of it as the sidekick that makes the star ingredient easier to use.

Vitamin C

75 mg

Structure / Function

Vitamin C is a nutrient your kid needs. Their body can't make it on its own. It supports a healthy immune system. It also gives everyday antioxidantA protector molecule. It steps in and defuses the unstable particles that would otherwise wear your cells down. support. One chewable has 75 mg. That's 83% of a child's Daily Value for vitamin C.

Vitamin C is a well-studied antioxidantA protector molecule. It steps in and defuses the unstable particles that would otherwise wear your cells down.. It helps protect cells from everyday free radicalsUnstable particles your body makes just from normal living (plus stress and pollution) that slowly damage cells over time, a bit like rust on metal.. It also supports the everyday work of your kid's immune system. It's the one nutrient here with a set Daily Value.

N-Acetyl-L-Cysteine USP

12 mg

Structure / Function

N-Acetyl-L-Cysteine (NAC) is part of the blend. It's a small amount at 12 mg.

NAC is a small supporting ingredient in this chewable. It's 12 mg.

These summaries describe each ingredient's role in normal physiology — they are not a claim to diagnose, treat, cure, or prevent any disease.

Where the science points

Hist Assist JR — influence by impact

Influence by impact

  • Infection60%
  • Environmental40%

A chewable blend. It helps steady your kid's histamine response. Quercetin, nettle, and bromelain support a calm season. Vitamin C adds everyday antioxidant support.

InfectionNutritionGut EnvironmentalMedicationLifestyleMind & MoodGeneticsHormonesSubstance

Hover a label to see what each one means.

Top focus

  • Steady everyday histamine response
  • Calm seasonal immune support
  • Daily antioxidant support

A chewable blend. It helps steady your kid's histamine response. Quercetin, nettle, and bromelain support a calm season. Vitamin C adds everyday antioxidant support.

See all 10 categories
  • Infection 3/5
  • Environmental 2/5
  • Substance 0/5
  • Nutrition 0/5
  • Mind & Mood 0/5
  • Medication 0/5
  • Lifestyle 0/5
  • Hormones 0/5
  • Gut 0/5
  • Genetics 0/5
Studies behind these scores
  1. Kaag & Lorentz, Cells 2023 (PMID 37998337); Naso, Trincianti, Tosca & Ciprandi, Nutrients 2025 (PMID 40362785)PubMed →
  2. Devkota & Hansbro, Molecules 2022 (PMID 36014458); Naso et al., Nutrients 2025 (PMID 40362785)PubMed →
  3. Lykkesfeldt & Carr, Adv Nutr 2023 (PMID 37992968)PubMed →

Scores show each ingredient's share of evidence-graded support for normal body function. They are not a measure of diagnosing, treating, curing, or preventing any disease.

Dr. Somer DelSignore, DNP, PNP-BC, MAPS

Your guide

Chosen by a clinician — not an algorithm.

Every Wholesome Root Nutraceuticals formula is selected by Dr. Somer DelSignore, DNP, PNP-BC, MAPS .You're not buying off a shelf. You're following a guide who has been where you are.

Meet your guide

DNP · Pediatric Nurse Practitioner · MAPS Fellow

What is Hist Assist JR for?
It's a daily chewable for kids. It supports everyday histamine and mast-cell balance. It supports your child's normal histamine balance. That helps them stay calm and comfortable. It also gives Vitamin C for a healthy immune system.
What's actually in it?
The blend leads with quercetin, a plant flavonoid. It also has stinging nettle leaf and bromelain, an enzyme from pineapple. You'll find Vitamin C at 83% of the Daily Value. There's also a small amount of NAC. Each serving is one chewable tablet. There are 60 in a container.
Why is there bromelain in it?
Bromelain is an enzyme from pineapple. It's in the blend to help your kid's body take in the quercetin. It's a helper ingredient, not the star.
How much should my kid take, and is it right for them?
For the right amount, please ask your practitioner. They can also tell you if this formula fits your kid's needs. They know your kid's full picture and can guide you. We don't give dosing or safety advice here.
Can my kid take this with their other supplements or medicine?
That's a great question for your practitioner. They can look at everything your kid is taking and tell you what fits. Please check with them before you combine anything.
Who picked this formula?
Dr. Somer picked this formula for the store. But the choice of whether it's right for your kid should come from your own practitioner. They know your kid's history and can guide how to use it.

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